`

Services

The S&D Lipopharma LLC is a research, consulting company intended to provide high quality glycolipids, carbohydrates, and other organic specialty chemicals of broad interests. We are also conducting new drug discovery ranging from glycolipid adjuvants and carbohydrate-based vaccines to other broadly defined medicines. We are offering both custom and standard products in containers according to your needs and delivered in a timely manner. We provide three major services: (1) consulting on carbohydrate related chemistry and glycobiology (2) collaborative research on new drug discovery (3) custom synthesis (4) analytical service.

 

1) Consulting

S&D Lipopharma is well equipped and versed in carbohydrates and glycolipids synthesis. Our consulting service covers all topics in synthetic organic chemistry of carbohydrates and glycolipids and applications of carbohydrate-based medicines. Recently, We have solved the long existing controversial issue in the area of glycolipid immunology. In our collaboration, glycolipids have been prepared and sent to over 2 dozens of laboratories around the world. Duo to the highly active nature of the glycolipids with which we work, trace impurities can impact results, and mistakes caused by impurities have been published by other researchers in multiple papers. We prepared pure and exact samples to our collaborators and eventually concluded that only alpha-glycosylceramides can trigger NKT cell response. S&D Lipopharma ever since is recognized and trusted worldwide by its precision and accuracy. We continue to serve our collaborators and customers from around the world with professionalism and expertise in the following areas:

  • All topics in the carbohydrates chemistry including protection deprotection strategy, glycosylation methodologies, tactics for oligosaccharides synthesis, C-glycoside synthesis, rare sugar synthesis, glycoconjugates as functional tools such as biological probes, prophylactic and therapeutic reagents. Design and synthesis of complex carbohydrates-based molecules of biological importance.


  • Glycolipids synthesis and characterizations and formulations for in vitro and in vivo tests. Glycolipids consist of a wide variety of classes ranging from monoglycosyllipids to higher order oligoglycosyllipids. Lipids are comprised of different fatty acids, mono- or di-acyl glycerol, sphingo or phytosphingoceramides, etc. Glycolipids are natural or optimized structures used widely as adjuvants of vaccines or other biological purposes. They originated from bacteria, viruses, fungi, and plants and animals and humans.


  • Phospholipids synthesis and formulation for in vitro and in vivo tests

  • Complex oligosaccharides synthesis

  • Design and synthesis of diverse glycoconjugates such as glycopeptides, glycoprotein, biotinylated glycolipids, biotinylated oligosaccharides, and other glycodiversified functional molecules.

2) Research

S&D Lipopharma in connection with its collaborators is centered in translational drug discovery in two areas; 1) discovery of glycolipids as adjuvants 2) development of carbohydrate based vaccines. Currently, we are seeking for extramural funding to continue these dynamic research projects. We are also interested to expand our research to other areas if appropriate funding is available.

 

3) Custom synthesis

Our custom manufacturing program consists of laboratory synthesis and rapid scale-up. The S&D Lipopharma LLC is staffed with highly skilled personnel whose main objective is to commercialize safe, reproducible and economical processes to proprietary or custom products. The majority of our staff holds PhD's with technical expertise in the synthesis of the following organic chemicals:

 
  • Endogenous, natural and synthetic glycolipids in formulated forms

  • Polysaccharides from different resources (bacteria, virus, fungi, plant, mammals, or/and cancer cells, etc.)

  • Complex carbohydrates of biological significance

  • Bioactive carbohydrate based natural products

  • Carbohydrate based functional molecules, specialty chemicals

  • Biotin or flourophore labelled glycans

We are able to develop samples for target compounds meeting your specifications and devise processes to make these compounds at scale.

S&D Lipopharma in connection with manufacturing facilities designed to achieve the rapid scale-up of your custom chemical needs is also in service. Our team is able to quickly develop a scale-up plan based on the results of collaborative efforts made on the laboratory scale. We believe that our efforts to develop customized and unique products forms the basis of a valuable partnership with our customers. This philosophy coupled with our flexibility in scale allows us to quickly manufacture intermediate size product batches.

 

4) Analytical service

At S&D Lipopharma, our philosophy is to insure that our material that is sent to you is characterized to the greatest extent possible to allow you to fully understand its properties and behavior in your process. To that end, S&D Lipopharma has established a state of the art characterization laboratory to control products' quality. we have the knowledge and capability to provide your team with detailed characterization information and methodologies. The following services are available:

  • 1H, 19F, 13C, 31P, 15N, 11B, and variable temperature NMR (1D & 2D)
  • FTIR
  • GC-MS
  • HPLC
  • UV
  • high resolution electrospray and MALDI MS
  • optical rotation
  • basic physical propeties: melting point, boiling point, density, etc.